In the field of “Genome stability & DNA repair’’ the research group of Dr Falk Butter offers the following PhD project:
Characterization of telomere binding proteins in zebrafish
Description:
During this project, we will establish transgenic as well as CRISPR-Cas knock-out lines of several recently reported telomere proteins and study their effects in vivo. We will apply state-of-the-art omics techniques (transcriptomics and proteomics) to obtain a global picture of gene regulation comparing germ line specific and somatic regulatory functions. Specific assays will be employed to investigate telomere length (teloblot, qFISH), effects on telomerase action (qTRAP), telomeric localization (live, confocal and superresolution microscopy). Additionally, in vitro studies will supplement the in vivo analysis making use of our strength in protein biochemistry (e.g. quantitative protein interaction studies).
We are looking for a highly motivated student with a degree in Molecular Biology, Biochemistry or related fields to join our lab. During this project, you will work with an exciting model organism and generate new strains. A strong sense of responsibility and the ability to work independently is required. We provide the opportunity to use diverse cell biological and biochemical methods during the project. The zebrafish work will be done in close collaboration with the Ketting group at IMB. The IMB supports cytometry, histology, microscopy and next generation sequencing by strong core facilities.
We offer
- The possibility to work on a cutting-edge project using state-of-the-art technology in a highly motivated research team
- A stimulating, diverse and international research environment
- Advanced training opportunities in scientific, technical and transferrable skills
- Fully funded positions
Required qualifications
- Master or Diploma
- Motivation to solve complex scientific problems
- Good communication skills in English
Further requirement:
- Two letters of reference
Starting date: 1 October 2018 or later
Duration of stipend/salary: 3 years, with the possibility of extension
Deadline for registration (exclusively online via web form): 15 May 2018
For further questions and contact information, please check our website:
http://www.imb.de/PhD
Please apply exclusively via our online form at:
https://www.imb.de/students-postdocs/international-phd-programme/apply-to-ipp/
