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PhD studentship # Marie Curie Early Stage Researcher # Germany#

  • ORGANISATION/COMPANY
    AiCuris Anti-infective Cures GmbH
  • RESEARCH FIELD
    Biological sciencesBiology
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    28/02/2017 23:00 – Europe/Brussels
  • LOCATION
    Germany › Wuppertal
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    42
  • EU RESEARCH FRAMEWORK PROGRAMME
    H2020 / Marie Skłodowska-Curie Actions
  • MARIE CURIE GRANT AGREEMENT NUMBER
    721484

Infectious diseases are still among the top 10 causes of death worldwide. The most relevant factor accounting for the high incidence of infectious diseases is the increase and spread of multi drug resistant (MDR) strains, which is leaving clinicians with very limited options to treat infections especially those from Gram-negative pathogens.
The bacterial cell envelope is still one of the best targets for antimicrobial discovery. Train2Target is an interdisciplinary project aiming at dissecting the biogenesis of the cell envelope of Gram-negative bacteria, in particular peptidoglycan biosynthesis and outer membrane assembly. The assembly of these structures is carried out by sophisticated molecular machines that function outside the cell and that need to be temporally and spatially orchestrated to ensure proper cell growth and division. The Train2Target project aims at dissecting at the molecular level the function and coordination of core envelope machineries: to this end interdisciplinary approaches based on an array of genetic, biochemical, biophysical and structural biology techniques will be used. Innovative in vivo and in vitro assays will be also developed to find molecules that alter the function and/or misbalance the coordination of envelope machineries thus providing new drugs to be developed as innovative antibiotics.

The consortium consists of partners with excellent scientific qualifications in multiple disciplines. In total there are 15 open ESR positions within Train2Target. During the appointment secondments will be performed at the premises of other partners to ensure multidisciplinary training and close collaborations.

An Early-Stage Researcher (ESR) will be recruited as a PhD candidate to perform research in antibacterial drug discovery targeting Gram-negative pathogens with the following aims:

• Identification of novel chemical classes to target key Peptidoglycan (PG) proteins of Gram-negative bacteria
• Development of suitable biochemical target assays for hit evaluation
• Testing of potential hit/ leads in animal models of infections
• Evaluation of further bacterial targets and assays for antibacterial drug discovery

More info:

https://euraxess.ec.europa.eu/jobs/138061

 

 

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