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Doctoral (PhD) student position in immunology, Karolinska Institutet, Stockholm, Sweden

Karolinska Institutet, Institutionen för mikrobiologi, tumör- och cellbiologi

Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet conducts research and teaching in immunology, infection biology, cell biology and cancer. MTChas about 430 active employees, including 100 PhD students, 50 postdoctoral researchers and 26 professors. Key words are multidisciplinary, bridging, translational, national andinternational collaborations.

A doctoral position is an available doctoral education project to which a PhD student is to be recruited. After the selection process the process for admission to doctoral education will commence. An admission decision will not be taken until an individual study plan has been approved by the departmental admission board.

For more information regarding doctoral (PhD) education, see: http://www.ki.se/doctoral.

Research group
The Department of Microbiology, Tumor and Cell Biology announces an opportunity to join the group of Prof. Karlsson Hedestam as a PhD student in immunology. The group has extensive experience in studies of B cell-mediated immunity and induction/maintenance of epitope-specific responses through the isolation of monoclonal antibodies and next generation sequencing of B cell receptor repertoires.

For more information about the research see http://ki.se/en/mtc/gunilla-karlsson-hedestam-group.

The doctoral education project and the duties of the student
The PhD studies correspond to 4 years of full-time studies. This includes lab work, courses, seminars, and presentation of results at meetings. Other responsibilities includedevelopment of methodology and work routines, literature review, statistical analysis and draft scientific manuscripts.

The project aims to investigate antigen-specific B cell responses induced by immunization using structurally defined, native-like viral antigens. The project will investigate different subsets of antigen-specific memory B cells isolated from diverse immune compartments. Single B cells will be sorted by flow cytometry and matching antibody heavy and light chains will be isolated by RT-PCR for production of monoclonal antibodies (MAbs). The MAbs will be characterized for their fine epitope specificities and functional properties. The project includes work with primary cell cultures, molecular biology, genetics and protein biochemistry.

Entry requirements for doctoral education at KI
To be eligible for doctoral education following requirements has to be met:

General entry requirements
A person meets the general entry requirements for doctoral/third-cycle/PhD education (according to Higher Education Ordinance Chapt 7, section 39) if he/she:

  1. has been awarded advanced/second-cycle/master qualification (i.e. master degree) or
  2. has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the second-cycle/master level, or
  3. has acquired substantially equivalent knowledge in some other way in Sweden or abroad.

Specific entry requirements
Proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school:
Proficiency in the English language can be documented by an internationally recognized test such as TOEFL or IELTS, see web-link below for more information.
Applicants who meet the general entry requirements (1 or 2 above) from a university in one of the Nordic countries fulfill the requirements in English.

For more information regarding general and specific entry requirements: http://ki.se/en/education/entry-requirements-eligibility-for-doctoral-education

Skills and personal qualities
Candidates should hold a Master degree in biomedicine with focus on molecular biology, immunology or cell biology. Previous experience with cell and molecular biology techniques are required. Applicants with experience with immunological and molecular methods, cell culture and expression of recombinant proteins in mammalian expression systems are prioritized. We are looking for a highly motivated, critically thinking and creative person. Excellent communication skills in written and spoken English are required.

Assessment criteria
A selection will be made among qualified applicants on the basis of the ability to benefit from doctoral education. Karolinska Institutet uses the following bases of assessment:
– Documented subject knowledge of relevance to the area of research
– Analytical skill
– Other documented knowledge or experience that may be relevant to doctoral studies in the subject

The qualifications of the applicants will be evaluated on an overall basis.

Terms and conditions
All doctoral students at KI receive financial support during their doctoral education and employment on a doctoral studentship is the most common sort of support. During the time between recruitment and admission a short-term employment can be offered for up to 6 months.

Application process
An application must contain the following documents in Swedish or English:

  • A personal letter and curriculum vitae
  • A copy of degree certificates and associated certificates
  • A copy of degree projects and any previous publications

The application is to be submitted through the MyNetwork recruitment system.

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